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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Synonyms:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Species:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
UniProtKB ID:
P42336, Q14CW1, Q99762
Gene ID:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Product Number
Description
Species Reactivity
Application
09-481
Anti-PI3 Kinase Antibody, p110α, from rabbit, purified by affinity chromatography,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot

Kits

Product Number
Description
Species
33-017
PI 3-Kinase HTRF® Assay; 1920 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Species
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Species
human
33-016
PI 3-Kinase HTRF® Assay; 384 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 1 plate.,
Species
human
33-037
PI 3-Kinase HTRF® Assay; 50,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 50,000 wells.,
Species
human

Proteins

Product Number
Description
Species
14-782-M
PI 3-Kinase (p110α(E542K)/p85α), Human, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E542K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Species
human
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Species
human
14-785-M
PI3 Kinase (p110α/p85α) murine, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p85α. Coexpressed by baculovirus in Sf21 insect cells. For use in Kinase Assays.,
Species
mouse
14-792-M
PI 3-Kinase (p110α(H1047R)/p85α), 10 µg, Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.,
Species
human
14-602-M
PI3 Kinase (p110α/p85α) Protein, active, 20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
Species
human