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Key Documents

SAB4502546

Sigma-Aldrich

Anti-BAX antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Apoptosis regulator BAX, BAX, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q07812

UniProt accession no.

Q07812

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BAX(581)

General description

Anti-BAX antibody detects endogenous levels of total BAX protein.
The BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) gene is mapped to human chromosome 19q13.33. It codes for α-helical globular protein. The protein contains eight amphipathic helices around a hydrophobic helix. Bax is known to be mostly localized in the cytoplasm.

Immunogen

The antiserum was produced against synthesized peptide derived from human Bax.

Immunogen Range: 133-182

Application

Anti-BAX, C-Terminal antibody produced in rabbit has been used in western blotting analysis.

Biochem/physiol Actions

BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) is predominantly associated with cellular homeostasis, cell cycle and pathogenesis of cell death particularly in cancer cells. In response to an apoptotic stimulus, Bax brings about mitochondrial dysfunction and apoptosis. Oligomerization of bax promotes mitochondrial outer membrane permeabilization.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma.
Godlewski J
Anticancer Research, 37(6), 2927-2937 (2017)
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner TP
Molecular Cell, 63(3), 485-497 (2016)
Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
Zhang J
Cell Death & Disease, 7, 1-9 (2016)
Wnt signal transduction pathway and apoptosis: a review.
Pecina-Slaus N
Cancer Cell International, 10:22, 1-5 (2010)
Guo-Liang Zhang et al.
Toxicology and applied pharmacology, 317, 33-40 (2017-01-17)
Zearalenone (ZEA) is an estrogenic mycotoxin mainly produced as a secondary metabolite by numerous species of Fusarium. Previous work showed that ZEA had a negative impact on domestic animals with regard to reproduction. The adverse effects and the mechanisms of
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