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N2515

Supelco

D-Norpropoxyphene maleate salt

analytical standard

Synonym(s):

1,2-Diphenyl-3-methyl-4-(methylamino)-2-butyl propionate

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About This Item

Empirical Formula (Hill Notation):
C21H27NO2 · C4H4O4
CAS Number:
38910-73-5
Molecular Weight:
441.52
MDL number:
MFCD00079481
UNSPSC Code:
41116107
PubChem Substance ID:
329818414
NACRES:
NA.24

grade

analytical standard

Quality Level

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

OC(=O)\C=C/C(O)=O.CCC(=O)OC(Cc1ccccc1)(C(C)CNC)c2ccccc2

InChI

1S/C21H27NO2.C4H4O4/c1-4-20(23)24-21(17(2)16-22-3,19-13-9-6-10-14-19)15-18-11-7-5-8-12-18;5-3(6)1-2-4(7)8/h5-14,17,22H,4,15-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

HCQPFYNZJNOOKN-BTJKTKAUSA-N

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000227544
0000167754
0000135558
119M4021V
13140605

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R S Wu et al.
Bioconjugate chemistry, 8(3), 385-390 (1997-05-01)
The synthesis of [S-(R,S)]-4-[[methyl[2-methyl-3-(1-oxopropoxy)-3, 4-diphenylbutyl]amino]-1-oxobutoxy]-2,5-pyrrolidinedione+ ++ (propoxyphene active ester, 2) is described. This was used as an intermediate to prepare a propoxyphene immunogen, [S-(R,S)]-4-[methyl][2-methyl-3-(1-oxopropoxy)-3,4-diphenylbuty l]-amino]- 1-oxobutyl-Bovine Thyroglobulin (3). This immunogen was then used to generate antibodies which demonstrate good cross-reactivity
T Lang-Jensen et al.
Pharmacology & toxicology, 64(2), 228-232 (1989-02-01)
In a double blind cross-over study 10 healthy male volunteers were given either 300 mg dextropropoxyphene napsylat (DP) or placebo daily for 16 days. The serum levels of DP and the metabolite nordextropropoxyphene were measured on day 3, 6 and
P Kintz et al.
Journal de toxicologie clinique et experimentale, 10(2), 89-94 (1990-03-01)
A method for the identification and quantification of dextropropoxyphene, norpropoxyphene, and methaqualone in plasma by GC/NPD is presented. The procedure employs cyclizine as the internal standard and requires no derivatization. After a single-step extraction, analysis is achieved in 8 min.
V Rigourd et al.
Journal of analytical toxicology, 32(9), 787-789 (2008-11-22)
Dextropropoxyphene (DP) and norpropoxyphene (NP) are commonly used in the treatment of postpartum pain. The drug is widely prescribed in Europe and Canada and has been recently approved for use in the U.S. Its safety during breastfeeding, however, has not
Bridgit Crews et al.
Journal of analytical toxicology, 33(7), 379-383 (2009-10-03)
A "dilute and shoot" method for measuring norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration
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