Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF51572572

Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%

GF92036235

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%

GF09436619

Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

GF06396532

Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%

GF01692952

Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%

GF15342016

Platinum, tube, 500mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%

GF32664113

Platinum, insulated wire, 2m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%

GF88232542

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%

GF09598809

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF47974056

Platinum, tube, 100mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%

GF87499906

Platinum, foil, 6mm disks, thickness 0.004mm, as rolled, 99.95%

GF99566410

Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%

GF52591462

Platinum, foil, 4mm disks, thickness 0.0075mm, as rolled, 99.95%

GF17993368

Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.95%