SML1210

Almotriptan malate

≥98% (HPLC)

• Synonym(s): 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate, PNU 180638
• Empirical Formula (Hill Notation): C₁₇H₂₅N₃O₂S · C₄H₆O₅
• CAS Number: 181183-52-8
• Molecular Weight: 469.55
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
• InChI key: QHATUKWEVNMHRY-UHFFFAOYSA-N

Description

Application

Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.

Biochem/physiol Actions

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable