PHG0007

MOPS

• Synonym(s): 3-(N-Morpholino)propanesulfonic acid, 4-Morpholinepropanesulfonic acid
• Empirical Formula (Hill Notation): C₇H₁₅NO₄S
• CAS Number: 1132-61-2
• Molecular Weight: 209.26
• Beilstein: 1106776
• EC Number: 214-478-5
• MDL number: MFCD00006183
• UNSPSC Code: 12161700
• NACRES: NA.21

Properties

• biological source: synthetic
• Quality Level: 400
• Assay: ≥99.5%
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: Endotoxin, microbial, and trace metals; tested
• pH: 2.5-4 (1 M in H₂O)
• useful pH range: 6.5-7.9
• pKa (25 °C): 7.2
• λ: 1 M in H₂O
• suitability: suitable for manufacturing use
• foreign activity: Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
• SMILES string: OS(=O)(=O)CCCN1CCOCC1
• InChI: 1S/C7H15NO4S/c9-13(10,11)7-1-2-8-3-5-12-6-4-8/h1-7H2,(H,9,10,11)
• InChI key: DVLFYONBTKHTER-UHFFFAOYSA-N

Description

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

MOPS is a biological buffer also referred to as a “Propane Sultone” buffer. The pKa of MOPS is 7.01 which make it an ideal candidate for medias and protein based buffer formulations to maintain a stable environment in solution. MOPS is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPS is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream). MOPS based buffers are used in purification bioprocesses of antibodies, peptides, proteins and blood components.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup