N3139

β-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate

powder, BioReagent, suitable for cell culture

• Synonym(s): Triphosphopyridine nucleotide sodium salt hydrate
• Empirical Formula (Hill Notation): C₂₁H₂₇N₇NaO₁₇P₃ · xH₂O
• CAS Number: 698999-85-8
• Molecular Weight: 765.39 (anhydrous basis)
• MDL number: MFCD00150480
• UNSPSC Code: 12352205
• PubChem Substance ID: 24897624
• NACRES: NA.75

Properties

• product line: BioReagent
• Assay: ≥98% (HPLC); ≥98% (spectrophotometric assay)
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 175-178 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: O[C@H]1[C@@H](O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP(OP(OC[C@H]3O[C@@H](N(C=N4)C5=C4C(N)=NC=N5)[C@H](OP(O)(O)=O)[C@@H]3O)([O-])=O)([O-])=O.O.[Na+]
• InChI: 1S/C21H28N7O17P3.Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);;1H2/q;+1;/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;;/m1../s1
• InChI key: CYQLUFJYVTUUFN-WUEGHLCSSA-M

Description

Application

β-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate has been used in the purification and crystallization of CHORD–Sgt1 cytochrome b 5 reductases (CS–b5R). It has also been used as a supplement in Dulbecco′s modified Eagle′s medium (DMEM)/F-12 medium for direct hepatic reprogramming using mouse embryonic fibroblasts (MEFs).

Biochem/physiol Actions

Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable cofactor that participates in cellular redox reactions. It acts as a hydride-accepting coenzyme and participates in substrate oxidation reactions during metabolism.

Electron acceptor

Packaging

Packaged by solid weight.

Analysis Note

Meets or exceeds NRC specifications and is comparable to any commercial preparation available.

Other Notes

This is the common form of NADP. Do not confuse with 3′−NADP or α-NADP.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable