B5438

Balsalazide disodium salt hydrate

• Synonym(s): 5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt hydrate
• Empirical Formula (Hill Notation): C₁₇H₁₃N₃Na₂O₆ · xH₂O
• CAS Number: 213594-60-6
• Molecular Weight: 401.28 (anhydrous basis)
• MDL number: MFCD18632541
• UNSPSC Code: 12352100
• PubChem Substance ID: 329773261
• NACRES: NA.25

Properties

• Assay: ≥99% (HPLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: O.[Na+].[Na+].Oc1ccc(cc1C([O-])=O)\N=N\c2ccc(cc2)C(=O)NCCC([O-])=O
• InChI: 1S/C17H15N3O6.2Na.H2O/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23;;;/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26);;;1H2/q;2*+1;/p-2/b20-19+;;;
• InChI key: ZZZXQZHSFPVNCR-HVARVCSCSA-L

Description

Biochem/physiol Actions

Balsalazide has antioxidative and anti-inflammatory properties. It inhibits superoxide production and was found to scavenge hypochlorite radicals. Balsalazide was shown to inhibit lipid peroxidation in rat intestinal mucosa. It was also shown to inhibit azoxymethane-induced colon carcinogenesis. In vivo, basalazide is cleaved through azoreduction to produce 4-aminobenzoyl-β-alanine, an inert carrier moiety, and 5-aminosalicylic acid (5-ASA).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable