A1752

Adenosine 5′-monophosphate sodium salt

from yeast, ≥99%

• Synonym(s): 5′-Adenylic acid, A-5′-P, AMP
• Empirical Formula (Hill Notation): C₁₀H₁₄N₅O₇P · xNa⁺ · yH₂O
• CAS Number: 149022-20-8
• Molecular Weight: 347.22 (anhydrous free acid basis)
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24890583
• NACRES: NA.51

Properties

• biological source: yeast
• Quality Level: 300
• Assay: ≥99%
• form: powder
• solubility: H₂O: soluble
• storage temp.: −20°C
• SMILES string: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.

Description

Application

Adenosine 5′-monophosphate sodium salt has been used:

• as a component of reactivation medium to reactivate mouse sperm extracted from caudae epididymides for sperm motility studies
• as a substrate in signal amplification by reversible exchange (SABRE) method to develop biocompatible SABRE hyperpolarization
• as a substrate in wheat and Aspergillus niger phytase, assay
• in luciferase assay to monitor intracellular α-synuclein oligomerization in S1S2 cells
• to study its effects on induction of therapeutic hypothermia and neuronal damage in a rat model of cardiac arrest (CA) and resuscitation

Biochem/physiol Actions

Adenosine 5′-monophosphate (5′-AMP) is used to enhance flavor in meat and poultry soups. It is also used as a food additive for specific nutritional purposes. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). Along with inosine monophosphate (IMP), AMP mediates the dissociation of skeletal muscle actomyosin to actin and myosin. Therefore, these two factors may be involved in causing the resolution of rigor mortis in muscles.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves