22244
Ceramide from bovine spinal cord
≥98.0% (TLC)
Synonym(s):
Bovine Spinal Cord Ceramide
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About This Item
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biological source
bovine spinal cord
Assay
≥98.0% (TLC)
form
solid
impurities
α-hydroxy fatty acids
solubility
chloroform/methanol (99:1): 20 mg/mL, clear, colorless
lipid type
sphingolipids
shipped in
wet ice
storage temp.
−20°C
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Application
Ceramide is used to investigate effects on programmed cell death (apoptosis) and insulin signaling.
Biochem/physiol Actions
Ceramide is a minor component of cell membranes. Activates atypical protein kinase C (e.g., PKCzeta) .
Preparation Note
from cerebrosides by a modification of the procedure by H.E. Carter et al., J. Lipid Res. 2, 228 (1961)
Other Notes
Sales restrictions may apply
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.
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