8.18731

Salicylic acid

for synthesis

• Synonym(s): Salicylic acid, 2-Hydroxybenzoic acid
• Empirical Formula (Hill Notation): C₇H₆O₃
• CAS Number: 69-72-7
• Molecular Weight: 138.12
• MDL number: MFCD00002439
• UNSPSC Code: 12352106
• EC Index Number: 200-712-3
• NACRES: NA.22

Properties

• vapor pressure: <1 hPa ( 100 °C)
• Quality Level: 200
• Assay: ≥99% (acidimetric)
• form: solid
• autoignition temp.: 500 °C
• potency: 1250-1580 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• technique(s): tissue culture: suitable
• pH: 2.4 ( in H₂O, saturated solution)
• bp: 211 °C/1013 hPa
• mp: 157-159 °C
• transition temp: flash point 157 °C
• solubility: water: 2 g/L at 20 °C
• density: 1.443 g/cm³ at 20 °C
• bulk density: 400‑500 kg/m³
• storage temp.: 2-30°C
• InChI: 1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
• InChI key: YGSDEFSMJLZEOE-UHFFFAOYSA-N

Description

Application

• Salicylic Acid and Water Stress: Investigates the impact of salicylic acid on the morphophysiology and essential oil profile of Eryngium foetidum under water stress conditions, highlighting its role in enhancing plant resilience and secondary metabolite production (Santos et al., 2024).


• Salicylic Acid in Plant Defense: Focuses on the usage of salicylic acid as an elicitor to boost the production of withanolides and phenolic acids in Withania somnifera, demonstrating its efficacy in improving secondary metabolite yield in plant biotechnological applications (Halder and Ghosh, 2024).


• Salicylic Acid in Natural Deep Eutectic Solvents: Describes the application of natural deep eutectic solvents containing salicylic acid for forming aqueous biphasic systems, presenting a novel method for drug extraction and highlighting its potential in pharmaceutical manufacturing (Ghaffari et al., 2024).

Safety Information

• Pictograms: GHS05,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H318 - H361d
• Precautionary Statements: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 314.6 °F - closed cup
• Flash Point(C): 157 °C - closed cup