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860595P

Avanti

C17 Lactosyl(β) Ceramide (d18:1/17:0)

Avanti Research™ - A Croda Brand 860595P, powder

Synonym(s):

D-Lactosyl-β-1,1′-N-Heptadecanoyl-D-erythro-Sphingosine

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About This Item

Empirical Formula (Hill Notation):
C47H89NO13
CAS Number:
1354699-26-5
Molecular Weight:
876.21
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860595P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860595P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O

General description

Lactosylceramide (LacCer) is a glycosphingolipid. It consists of a hydrophobic ceramide lipid and a hydrophilic sugar moiety. LacCer is expressed abundantly in the nervous system and myelin sheath.

Biochem/physiol Actions

Lactosylceramide (LacCer) is a structural and signaling lipid. It is implicated in signal transduction, cell adhesion and host-tissue pathogen interactions. LacCer modulates cell proliferation and apoptosis. It is involved in regulating cellular stress response and microbial pathogenesis. LacCer regulates innate immune responses. It helps in microbial attachment and also acts as an adhesion receptor for pathogens.

Packaging

5 mL Amber Glass Screw Cap Vial (860595P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharide, 191, 106-114 (2009)
Daniela Couto et al.
Chemistry and physics of lipids, 191, 106-114 (2015-09-01)
Galactosylceramide (GalCer) and lactosylceramide (LacCer) are structural and signaling lipids, playing important roles in signal transduction and cell adhesion. They are especially abundant in the nervous system and in important components of the myelin sheath. Although neurodegenerative disorders are associated
Jarod A Fincher et al.
Scientific reports, 9(1), 17508-17508 (2019-11-27)
Neutral lipids have been implicated in a host of potentially debilitating human diseases, such as heart disease, type-2 diabetes, and metabolic syndrome. Matrix-assisted laser desorption ionization (MALDI), the method-of-choice for mass spectrometry imaging (MSI), has led to remarkable success in

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