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860543P

Avanti

C12 Glucosyl(β) Ceramide (d18:1/12:0)

Avanti Research™ - A Croda Brand 860543P, powder

Synonym(s):

D-glucosyl-β-1,1′-N-lauroyl-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C36H69NO8
CAS Number:
111956-48-0
Molecular Weight:
643.93
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860543P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860543P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

InChI

1S/C36H69NO8/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-30(39)29(28-44-36-35(43)34(42)33(41)31(27-38)45-36)37-32(40)26-24-22-20-17-12-10-8-6-4-2/h23,25,29-31,33-36,38-39,41-43H,3-22,24,26-28H2,1-2H3,(H,37,40)/b25-23+/t29-,30+,31?,33+,34?,35?,36+/m0/s1

InChI key

IYCYEZLMOLRFAN-QGJHTTTBSA-N

Application

C12 Glucosyl(β) Ceramide (d18:1/12:0) or D-glucosyl-β-1,1′-N-lauroyl-D-erythro-sphingosine has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs). It may be used as an internal standard to spike cell lysate and to quantify lipid species using fourier transform mass spectrometry (FTMS) analysis. It may also be used as an internal standard for lipid extraction in U87MG (human glioma cell line).

Packaging

5 mL Amber Glass Screw Cap Vial (860543P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Hernandez-Tiedra S, et al.
Autophagy, 12(11), 2213-2229 (2016)
Shelly J Krebs et al.
Immunity, 50(3), 677-691 (2019-03-17)
Lineage-based vaccine design is an attractive approach for eliciting broadly neutralizing antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have features indicative of unusual recombination and/or development. From an individual in the prospective RV217 cohort, we identified
David B Iaea et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(4), 158609-158609 (2020-01-10)
STARD4, a member of the evolutionarily conserved START gene family, is a soluble sterol transport protein implicated in cholesterol sensing and maintenance of cellular homeostasis. STARD4 is widely expressed and has been shown to transfer sterol between liposomes as well
Christophe A C Freyre et al.
Molecular cell, 76(5), 811-825 (2019-10-20)
Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. The mechanisms coupling these organelles are, however, poorly understood
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main

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