912123
Trimethyl chitosan
medium molecular weight, degree of quaternization: 40- 60%
Synonym(s):
N,N,N-trimethyl chitosan, Chitosan trimethyl, Mucoadhesive polymers, TMC, TMC Chitosan
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
Recommended Products
![B-[4-(1,2,2-Triphenylethenyl)phenyl]boronic acid](/deepweb/assets/sigmaaldrich/product/structures/121/044/864e0829-e1de-4170-aae4-16c2b3ce4111/640/864e0829-e1de-4170-aae4-16c2b3ce4111.png)
Application
Chitosan offers remarkable biological properties, it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.
The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
BOONYO W, et al.
Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
Preparation and NMR characterization of highly substituted IV-trimethyl chitosan chloride.
A B Sieval, et al.
Carbohydrate Polymers, 36, 157-165 (1998)
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
Rieux A D, et al.
Polymer Science (2011)
J H Hamman et al.
Drug development and industrial pharmacy, 29(2), 161-172 (2003-03-22)
N-trimethyl chitosan chloride (TMC) is a polycation that enhances drug transport across epithelia by opening tight junctions. The degree of quaternization of TMC determines the number of positive charges available on the molecule for interactions with the negatively charged sites
Amir K Varkouhi et al.
Bioconjugate chemistry, 21(12), 2339-2346 (2010-11-06)
N,N,N-Trimethylated chitosan (TMC) is a biodegradable polymer emerging as a promising nonviral vector for nucleic acid and protein delivery. In the present study, we investigated whether the introduction of thiol groups in TMC enhances the extracellular stability of the complexes
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service