- Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.
Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.
Scientific reports (2017-05-21)
Guang-Yuh Chiou, Tzu-Wei Yang, Chi-Chou Huang, Chia-Ying Tang, Jung-Yi Yen, Ming-Chang Tsai, Hsuan-Yi Chen, Nurul Fadhilah, Chun-Che Lin, Yuh-Jyh Jong
PMID28526879
RESUMEN
Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this report, we demonstrated that the RNA-binding protein Musashi-1 enhanced the development of CD44
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