- Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III.
Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III.
Journal of lipid research (2017-04-04)
Manja Koch, Jeremy D Furtado, Gordon Z Jiang, Brianna E Gray, Tianxi Cai, Frank Sacks, Anne Tjønneland, Kim Overvad, Majken K Jensen
PMID28365588
RESUMEN
The presence of apoC-III on HDL impairs HDL's inverse association with coronary heart disease (CHD). Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. The aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3,631 participants from the Diet, Cancer, and Health study originally selected for a case-cohort study (36% women; age 50-65 years) who were all free of CHD. Greater adiposity and less activity were associated with higher HDL containing apoC-III and lower HDL lacking apoC-III. Per each 15 cm higher waist circumference, the level of HDL containing apoC-III was 2.8% higher (95% CI: 0.4, 5.3;
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