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Merck

Catalytic enantioselective thioester aldol reactions that are compatible with protic functional groups.

Journal of the American Chemical Society (2005-05-19)
Derek Magdziak, Gojko Lalic, Hong Myung Lee, Kevin C Fortner, Allen D Aloise, Matthew D Shair
RESUMEN

This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.

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Sigma-Aldrich
3-Hydroxy-4-nitrobenzaldehyde, 97%