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Merck

T cell recognition of beryllium.

Current opinion in immunology (2013-08-28)
Shaodong Dai, Michael T Falta, Natalie A Bowerman, Amy S McKee, Andrew P Fontenot
RESUMEN

Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by a hypersensitivity to beryllium and characterized by the accumulation of beryllium-specific CD4(+) T cells in the lung. Genetic susceptibility to beryllium-induced disease is strongly associated with HLA-DP alleles possessing a glutamic acid at the 69th position of the β-chain (βGlu69). The structure of HLA-DP2, the most prevalent βGlu69-containing molecule, revealed a unique solvent-exposed acidic pocket that includes βGlu69 and represents the putative beryllium-binding site. The delineation of mimotopes and endogenous self-peptides that complete the αβTCR ligand for beryllium-specific CD4(+) T cells suggests a unique role of these peptides in metal ion coordination and the generation of altered self-peptides, blurring the distinction between hypersensitivity and autoimmunity.

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Sigma-Aldrich
Beryllium, chunks, 99.9%
Beryllium, wire reel, 0.1m, diameter 0.5mm, annealed and clean, 99%
Beryllium, wire reel, 0.5m, diameter 0.125mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.05m, diameter 0.356mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.1m, diameter 0.85mm, annealed and clean, 99%
Beryllium, wire reel, 0.2m, diameter 0.356mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.3m, diameter 0.356mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.5m, diameter 0.25mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.5m, diameter 0.356mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.1m, diameter 0.05mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.2m, diameter 0.25mm, annealed and clean, 99.7%
Beryllium, wire reel, 1m, diameter 0.125mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.05m, diameter 0.5mm, annealed and clean, 99%
Beryllium, wire reel, 0.1m, diameter 0.125mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.1m, diameter 0.25mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.1m, diameter 0.356mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.2m, diameter 0.5mm, annealed and clean, 99%
Beryllium, wire reel, 0.2m, diameter 0.75mm, annealed and clean, 99%
Beryllium, wire reel, 0.5m, diameter 0.05mm, annealed and clean, 99.7%
Beryllium, wire reel, 1m, diameter 0.25mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.05m, diameter 0.25mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.1m, diameter 0.75mm, annealed and clean, 99%
Beryllium, wire reel, 0.2m, diameter 0.125mm, annealed and clean, 99.7%
Beryllium, wire reel, 0.2m, diameter 0.6mm, annealed and clean, 99%
Beryllium, wire reel, 0.05m, diameter 0.6mm, annealed and clean, 99%
Beryllium, wire reel, 0.05m, diameter 0.75mm, annealed and clean, 99%
Beryllium, wire reel, 0.05m, diameter 0.85mm, annealed and clean, 99%
Beryllium, wire reel, 0.1m, diameter 0.6mm, annealed and clean, 99%