SML3588

J147

≥98% (HPLC)

• Sinónimos: (E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N′-(3-methoxybenzylidene)acetohydrazide, 2,2,2-Trifluoro-acetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide, J 147
• Fórmula empírica (notación de Hill): C₁₈H₁₇F₃N₂O₂
• Número de CAS: 1807913-16-1
• Peso molecular: 350.33
• MDL number: MFCD25976644
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: COC1=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=CC=C1

Descripción

Biochem/physiol Actions

J147 is a broadly neuroprotective (in multiple assays) compound that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice. J147 has neurotrophic and BDNF-like activities that are independent of the BDNF receptor, and TrkB. Also it appears that J147 has a small but significant effect on Ab metabolism by reducing Ab1–42 in the soluble fraction of the hippocampus.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable