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Merck
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Documentos clave

SML0762

Sigma-Aldrich

Enzastaurin

≥98% (HPLC)

Sinónimos:

3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione, D04014, LY-317615, LY317615

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About This Item

Fórmula empírica (notación de Hill):
C32H29N5O2
Número de CAS:
170364-57-5
Peso molecular:
515.60
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

condiciones de almacenamiento

desiccated

color

, light orange to dark orange-red

solubilidad

DMSO: 10 mg/mL, clear (warmed)

temp. de almacenamiento

−20°C

cadena SMILES

N1C(=O)C(=C(C1=O)c6c7c([n](c6)C)cccc7)c2c3c([n](c2)C4CCN(CC4)Cc5ncccc5)cccc3

InChI

1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)

Clave InChI

AXRCEOKUDYDWLF-UHFFFAOYSA-N

Aplicación

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

Acciones bioquímicas o fisiológicas

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.
Enzastaurin is a potent and PKCβ proffering inhibitor.
It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

Características y beneficios

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H413

Consejos de prudencia

P273 - P301 + P312 + P330

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Chronic 4

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000169327
0000176584
0000173874
0000173874
0000169327

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Visite la Librería de documentos

Staurosporine allows dystrophin expression by skipping of nonsense-encoding exon
Atsushi N
Brain & Development (2016)
Enzastaurin: A lesson in drug development.
Bourhill T
Critical Reviews in Oncology/Hematology (2017)
Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma.
Fabro, et al.
Frontiers in Oncology, 12, 1012236-1012236 (2022)
Shannon M White et al.
Developmental cell, 49(3), 425-443 (2019-05-08)
Merlin/NF2 is a bona fide tumor suppressor whose mutations underlie inherited tumor syndrome neurofibromatosis type 2 (NF2), as well as various sporadic cancers including kidney cancer. Multiple Merlin/NF2 effector pathways including the Hippo-YAP/TAZ pathway have been identified. However, the molecular
Mehdi Bouhaddou et al.
Cell, 182(3), 685-712 (2020-07-10)
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a

Artículos

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

Glycogen Synthase Kinase 3 (GSK-3) Overview

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

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Protocolos

PKB/Akt

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