SAB4501060
Anti-GAB1 antibody produced in rabbit
affinity isolated antibody
Sinónimos:
GRB2-associated binder 1, GRB2-associated-binding protein 1, growth factor receptor bound protein 2-associated protein 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Productos recomendados
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 76 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GAB1(2549)
Categorías relacionadas
General description
Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.
The GRB2 associated binding protein 1 (GAB1) protein is encoded by the gene mapped to human chromosome 4q31.21. The encoded protein belongs to the Grb2-associated binding protein family. GAB1 protein structure contains pleckstrin homology domain and tyrosine residues. Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human GAB1.
Immunogen Range: 644-674
Immunogen Range: 644-674
Application
Anti-GAB1 antibody produced in rabbit has been used in proximity ligation assay (1:100) and western blotting.
Biochem/physiol Actions
GRB2 associated binding protein 1 (GAB1) acts as a scaffold protein for protein-protein interaction. It regulates growth factor receptors and enhances signal transduction of multiple intracellular signaling pathways, such as phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT)/ mammalian target of rapamycin (mTOR) signaling pathways. Upregulated expression of GAB1 contributes to the progression of various types of cancer including human oral squamous cell carcinoma (OSCC), breast cancer, colorectal cancer, hepatocellular carcinoma, and ovarian cancer. Therefore, knockdown of the GAB1 gene can be considered as a potential therapeutic strategy for treating breast cancer and OSCC.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Xiao Wang et al.
Journal of experimental & clinical cancer research : CR, 38(1), 27-27 (2019-01-23)
Breast cancer (BCa) remains as the second leading cause of cancer-related death in women worldwide. The majority of the deaths are due to its progression to metastatic BCa. Although Grb2-associated binding protein 1 (Gab1) has been implicated in tumor proliferation
Ethar Al-Husseinawi et al.
Pathology, 51(6), 610-614 (2019-08-25)
The Grb2-associated binding proteins are a family of platform proteins involved in signalling transduction pathways. A major family member, Gab1, modulates the effect of growth factor receptors and intracellular signalling pathways, including the phosphatidylinositol 3-kinase and AKT/mTOR signalling pathways. We
Luyong Xu et al.
Oncology research, 26(4), 617-624 (2017-09-13)
Grb2-associated binder 1 (Gab1) is often aberrant in cancerous cells and tissues, whose alteration is responsible for aggressive phenotypes. In this study, we examined the Gab1 expression in human oral squamous cell carcinoma (OSCC) tissues and investigated the cellular and
Rui Xu et al.
Genetics and molecular biology, 46(2), e20220277-e20220277 (2023-06-05)
Long non-coding RNA AK001796 was initially identified altered in lung cancer. Recent research showed it could participate in the prognosis of hepatocellular carcinoma (HCC). However, the general biological role of AK001796 and its underlying mechanisms in HCC remain unclear. Here
Microarray analysis of androgenetic and senescent alopecia: comparison of gene expression shows two distinct profiles.
Pratima Karnik et al.
Journal of dermatological science, 72(2), 183-186 (2013-07-28)
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