P6374
p53 human
recombinant, expressed in baculovirus infected Sf21 cells
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.25
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in baculovirus infected Sf21 cells
Ensayo
≥90% (SDS-PAGE)
Formulario
aqueous solution
técnicas
dot blot: suitable
Nº de acceso UniProt
aplicaciones
genomic analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TP53(7157)
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Descripción general
p53 protein is composed of an N-terminal domain with a transactivation domain and proline-rich region, a central core-DNA binding domain, and a C-terminal domain with tetramerization and regulatory domains. The TP53 gene which encodes for the p53 protein is mapped on the human chromosome at 17p13.1.
Aplicación
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
p53 human has been used in dot blot.
Acciones bioquímicas o fisiológicas
In addition, p53 was recently shown to induce differentiation of human embryonic stem cells. The effect is dependent on the DNA binding activity of p53.
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
p53 protein acts as a transcription factor that participates in regulating positively or negatively the expression of several responsive genes. It plays a role in regulating angiogenesis, cellular senescence, autophagy, cell survival, differentiation, and oxidative stress. Mutations in the TP53 gene lead to Li Fraumeni cancer syndrome.
Propiedades físicas
Histidine-tagged, full length human p53
Forma física
Supplied as a solution in 20 mM Tris-HCl, pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA, and 1 mM DTT.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Fiamma Mantovani et al.
Cell death and differentiation, 26(2), 199-212 (2018-12-13)
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex
p53: structure, function and therapeutic applications
Bai L and Zhu W
Journal of Cancer Molecules, 2(4), 141-153 (2006)
Adam Shlien et al.
American journal of human genetics, 87(5), 631-642 (2010-11-09)
DNA copy-number variations (CNVs) underlie many neuropsychiatric conditions, but they have been less studied in cancer. We report the association of a 17p13.1 CNV, childhood-onset developmental delay (DD), and cancer. Through a screen of over 4000 patients with diverse diagnoses
Abhinav K Jain et al.
PLoS biology, 10(2), e1001268-e1001268 (2012-03-06)
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of human
Karen H Vousden et al.
Nature reviews. Molecular cell biology, 8(4), 275-283 (2007-03-24)
As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development
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