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Merck
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Key Documents

P3513

Sigma-Aldrich

Poly-L-lysine, succinylated

mol wt >50,000

Sinónimos:

Modified Lysine Copolymer

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About This Item

MDL number:
MFCD00165425
UNSPSC Code:
12352209
NACRES:
NA.26

form

powder or solid

mol wt

>50,000

color

white to faint yellow

application(s)

cell analysis

storage temp.

−20°C

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Application

Succinylated poly-L-lysine has been used to bind (Gly)3-Arg-bradykinin to study its hydrolysis by brain endopeptidases and pancreatic proteinases.

Biochem/physiol Actions

Poly-L-lysine is a cationic polymer. It is mainly used for immobilizing cells to glass substrates or negatively charged substrates.
An intermediate for coupling proteins to poly-L-lysine.

Analysis Note

Molecular weight based on precursor poly-L-lysine viscosity. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Susceptibility of a Peptide Derived from Bradykinin to Hydrolysis by Brain Endo-oligopeptidases and Pancreatic Proteinases*
Antonio C. M. Camargo
The Journal of Biological Chemistry, 254(12), 5304-5307 (1979)
Sofia Helena Linnea Frost et al.
Cancer biotherapy & radiopharmaceuticals, 26(6), 727-736 (2011-11-18)
Avidin-coupled monoclonal antibody MX35 (avidin-MX35) and astatine-211-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) were administered in mice to assess potential efficacy as an intraperitoneal (i.p.) therapy for microscopic tumors. We aimed to establish a timeline for pretargeted radioimmunotherapy using these substances, and
Effects of poly(L-lysine) substrates on attached Escherichia coli bacteria.
Colville K
Langmuir, 26(4), 2639-2644 (2010)
V S Trubetskoy et al.
Nucleic acids research, 27(15), 3090-3095 (1999-08-24)
DNA can be condensed with an excess of poly-cations in aqueous solutions forming stable particles of submicron size with positive surface charge. This charge surplus can be used to deposit alternating layers of polyanions and polycations on the surface surrounding
M R Hamblin et al.
British journal of cancer, 89(5), 937-943 (2003-08-28)
Conjugates between photosensitisers (PS) and charged polymeric carriers are under investigation for photodynamic therapy of cancer and may allow targeting to certain cell types or compartments in tumours. Covalent attachment of polyethylene glycol to macromolecules (pegylation) may alter their pharmacokinetics
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