H2042

Histone H2A human

• Sinónimos: Histone, Human
• Número de CAS: 1523001-32-2
• UNSPSC Code: 12352202
• NACRES: NA.25

Propiedades

• biological source: human
• Quality Level: 200
• recombinant: expressed in E. coli
• form: liquid
• concentration: 1 mg/mL
• UniProt accession no.: Q16777
• application(s): cell analysis
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... H2AC20(8338)

Descripción

General description

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

Application

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

Biochem/physiol Actions

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

Physical form

Supplied in 20 mM Na₃PO₄, pH 7.0, 0.3 M NaCl and 1 mM EDTA

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H350
• pcodes: P201 - P308 + P313
• Hazard Classifications: Carc. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable