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B169

Sigma-Aldrich

BRL 37344 sodium salt hydrate

solid

Sinónimos:

(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate, BRL 37344A

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About This Item

Fórmula empírica (notación de Hill):
C19H21ClNNaO4 · xH2O
Número de CAS:
127299-93-8
Peso molecular:
385.82 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24277764
NACRES:
NA.77

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: 18 mg/mL, clear (warmed)

SMILES string

O.[Na+].C[C@H](Cc1ccc(OCC([O-])=O)cc1)NC[C@H](O)c2cccc(Cl)c2

InChI

1S/C19H22ClNO4.Na.H2O/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);;1H2/q;+1;/p-1/t13-,18+;;/m1../s1

InChI key

YTPAKDODIXRQTF-BNTHFPBMSA-M

Gene Information

human ... ADRB3(155)

Biochem/physiol Actions

BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic; store desiccated.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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S Tsujii et al.
Physiology & behavior, 63(4), 723-728 (1998-04-02)
This study evaluated the effect of peripheral injections of a beta3 adrenergic agonist, BRL-37,344 on food intake and whether this inhibition could be blocked by a nonspecific beta-adrenergic antagonist, propranolol, given peripherally or into the central nervous system. When BRL-37,344
M A Oriowo et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 22-27 (1996-04-01)
The stimulation by BRL 37344 of lipolysis in rat adipose tissues, and of relaxation of the rat distal colon, is mediated by the beta-3 adrenoceptor. The stereochemical requirements of the beta-3 adrenoceptor are poorly understood. The activities of the four
K Koike et al.
European journal of pharmacology, 334(2-3), 217-221 (1997-11-22)
Beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum was investigated by studying the effects of the beta3-adrenoceptor agonists, BRL37344A [(R*,R*)-(+/-)-4-[2'-[2-hydroxy-2-(3-chlorophenyl) ethylamino] propyl] phenoxyacetic acid sodium salt sesquihydrate] and BRL35135A [(R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamine] propyl] phenoxyacetate hydrobromide]. BRL37344A and BRL35135A caused dose-dependent relaxation of
Ziwen Wang et al.
Molecular medicine (Cambridge, Mass.), 26(1), 54-54 (2020-06-07)
Our objective was to investigate the efficacy of the beta-3 adrenergic receptor (β3-AR) agonist BRL37344 for the prevention of liver steatosis and inflammation associated with nonalcoholic fatty liver disease (NAFLD). Four groups were established: a control group (given a standard
Junyu Lai et al.
Journal of cellular biochemistry, 120(10), 17872-17886 (2019-06-05)
Partial bladder outlet obstruction (PBOO) promotes bladder detrusor hyperplasia, increases bladder pressure, and decreases bladder compliance. To extensively explore its underlying mechanism, our study aimed to investigate the effect of pathological hydrostatic pressure on human bladder smooth muscle cell (hBSMC)
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