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Y0000701

Metolazone

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C16H16ClN3O3S
Número de CAS:
17560-51-9
Peso molecular:
365.83
MDL number:
MFCD00069304
UNSPSC Code:
41116107
PubChem Substance ID:
329831104
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

metolazone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

Inchi Key

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metolazone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Domenic A Sica
Congestive heart failure (Greenwich, Conn.), 9(2), 100-105 (2003-04-03)
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant to loop diuretic therapy alone. Metolazone is a thiazide-type diuretic that is characterized by slow and sometimes erratic absorption when administered as
Pre-dosing metolazone with loop diuretic combination regimens.
Raymond A Lorenz et al.
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 33(1), 78-79 (2006-03-17)
Monimoy Banerjee et al.
Biochemical pharmacology, 92(2), 389-402 (2014-09-03)
Human pregnane X receptor (hPXR) regulates the expression of drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and drug transporters such as multidrug-resistance protein 1 (MDR1). PXR can be modulated by small molecules, including Federal Drug Administration (FDA)-approved drugs, thus altering drug
Mohammed I Walash et al.
Luminescence : the journal of biological and chemical luminescence, 29(5), 462-470 (2013-09-03)
A new, specific and sensitive reversed-phase high-performance liquid chromatography method was developed for the simultaneous determination of metolazone (MET) and losartan potassium (LOS). Good chromatographic separation was achieved within 6.0 min on a 150 × 4.6 mm i.d., 5 µm Waters, Ireland
Lucie Nováková et al.
Analytica chimica acta, 853, 637-646 (2014-12-04)
The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic doping agents was analyzed, in both ESI+ and ESI- modes.
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