538927

15d-PGJ₂

A metabolite of PGD₂that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected NIH/3T3 cells and for PPARγ response element (PPRE) in CV-1 cells.

• Sinónimos: 15d-PGJ₂, Prostaglandin J₂, 15-Deoxy-Δ ^12,14, PPAR Agonist VII, PPARγ Agonist VI
• Fórmula empírica (notación de Hill): C₂₀H₂₈O₃
• Número de CAS: 87893-55-8
• Peso molecular: 316.43
• MDL number: MFCD00065806
• UNSPSC Code: 12352211
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: oil
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
• InChI key: VHRUMKCAEVRUBK-GODQJPCRSA-N

Descripción

General description

A metabolite of PGD₂ that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A natural ligand for PPARγ-dependent adipogenesis

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Petrova, T.V., et al. 1999. Proc. Natl. Acad. Sci. USA96, 4668.
Ricote, M., et al. 1998. Nature 391, 79.
Forman, B.M., et al. 1995. Cell 83, 803.
Kliewer, S.A., et al. 1995. Cell83, 813.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable