230950

Ciglitazone

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

• Sinónimos: Ciglitazone, (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
• Fórmula empírica (notación de Hill): C₁₈H₂₃NO₃S
• Número de CAS: 74772-77-3
• Peso molecular: 333.45
• MDL number: MFCD00865499
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: tan
• solubility: DMSO: ≥25 mg/mL; ethanol: ≥25 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
• InChI key: YZFWTZACSRHJQD-UHFFFAOYSA-N

Descripción

General description

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 3 µM).

Biochem/physiol Actions

Cell permeable: no

EC50 = 3 µM as PPARγ agonist

Primary Target
Selective PPARγ agonist

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable