911410

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average M_n 5,000, PLGA average M_n 10,000, lactide:glycolide 80:20

• Sinónimos: PEG-PLGA, PEG5K-PLGA10K, Polyethylene glycol, mPEG-b-PLGA
• Fórmula lineal: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• UNSPSC Code: 12352112
• NACRES: NA.23

Propiedades

• form: powder
• feed ratio: lactide:glycolide 80:20
• mol wt: PEG average M_n 5,000 (by NMR); PLGA average M_n 10,000 (by NMR)
• impurities: ≤500 ppm (GC)
• color: white
• storage temp.: −20°C

Descripción

Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable