909998

2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid

≥95%

• Sinónimos: 2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₂-acid
• Fórmula empírica (notación de Hill): C₁₅H₂₈O₆
• Peso molecular: 304.38
• UNSPSC Code: 12352200

Propiedades

• assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• functional group: carboxylic acid; ester
• storage temp.: 2-8°C
• SMILES string: CC(C)(OC(CCCCCCOCCOCC(O)=O)=O)C

Descripción

Application

This heterobifunctional, PEGylated crosslinker 2-(2-((7-(tert-butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable