902667

Propargyl-PEG6-acid

• Sinónimos: 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Fórmula empírica (notación de Hill): C₁₆H₂₈O₈
• Número de CAS: 1951438-84-8
• Peso molecular: 348.39
• Número MDL: MFCD28950778
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• Ensayo: ≥95%
• Formulario: liquid
• idoneidad de la reacción: reaction type: click chemistry; reagent type: cross-linking reagent
• índice de refracción: n/D 1.469
• grupo funcional: alkyne; carboxylic acid
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• Clave InChI: XRSJYQQOJNYUDV-UHFFFAOYSA-N

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable