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402516

Sigma-Aldrich

1H-Pyrazole-1-carboxamidine hydrochloride

99%

Sinónimos:

1-Amidinopyrazole hydrochloride, Praxadine

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About This Item

Fórmula empírica (notación de Hill):
C4H6N4 · HCl
Número de CAS:
4023-02-3
Peso molecular:
146.58
Beilstein/REAXYS Number:
5448758
EC Number:
429-520-1
MDL number:
MFCD00210087
UNSPSC Code:
12352100
PubChem Substance ID:
24865095
NACRES:
NA.22

assay

99%

form

powder

mp

167-170 °C (lit.)

SMILES string

Cl[H].NC(=N)n1cccn1

InChI

1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H

InChI key

RBZRMBCLZMEYEH-UHFFFAOYSA-N

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General description

1H-Pyrazole-1-carboxamidine hydrochloride, a pyrazole derivative, is a heterocyclic compound. It is widely used in drug syntheses studies. Pyrazole ring forms the main core of various nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs.

Application

1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies:
  • Preparation of guanidylated hollow fiber membranes.
  • Guanylation of amines and in peptide synthesis.
  • Synthesis of bis-guanidinium-cholesterol derivatives.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hironori Izawa et al.
Biomolecules, 9(7) (2019-07-10)
In order to synthesize a promising material for developing a novel peptide/protein delivery system, guanidinylation of chitooligosaccharides with 1-amidinopyrazole hydrochloride was investigated herein. The production of guanidinylated chitooligosaccharides was demonstrated by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and elemental
J P Vigneron et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9682-9686 (1996-09-03)
Two cationic lipids, bis-guanidinium-spermidine-cholesterol (BGSC) and bis-guanidinium-trencholesterol (BGTC)-cholesterol derivatives bearing two guanidinium groups-have been synthesized and tested as artificial vectors for gene transfer. They combine the membrane compatible features of the cholesterol subunit and the favorable structural and high pKa
1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis.
Bernatowicz MS, et al.
The Journal of Organic Chemistry, 57(8), 2497-2502 (1992)
Thomas D Michl et al.
Acta biomaterialia, 108, 168-177 (2020-03-18)
Amphiphilic polymers bearing cationic moieties are an emerging alternative to traditional antibiotics given their broad-spectrum activity and low susceptibility to the development of resistance. To date, however, much remains unclear regarding their mechanism of action. Using functional assays (ATP leakage
Anna Yu Spivak et al.
Steroids, 154, 108530-108530 (2019-11-05)
A series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their antimicrobial activity against the growth of four bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA))
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