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  • Survival in sensitized lung transplant recipients with perioperative desensitization.

Survival in sensitized lung transplant recipients with perioperative desensitization.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2015-01-24)
K J Tinckam, S Keshavjee, C Chaparro, D Barth, S Azad, M Binnie, C W Chow, M de Perrot, A F Pierre, T K Waddell, K Yasufuku, M Cypel, L G Singer
ABSTRACT

Donor-specific HLA antibodies (DSA) have an adverse effect on short-term and long-term lung transplant outcomes. We implemented a perioperative strategy to treat DSA-positive recipients, leading to equivalent rejection and graft survival outcomes. Pretransplant DSA were identified to HLA-A, B, C, DR and DQ antigens. DSA-positive patients were transplanted if panel reactive antibody (PRA) ≥30% or medically urgent and desensitized with perioperative plasma exchange, intravenous immune globulin, antithymocyte globulin (ATG), and mycophenolic acid (MPA). PRA-positive/DSA-negative recipients received MPA. Unsensitized patients received routine cyclosporine, azathioprine and prednisone without ATG. From 2008-2011, 340 lung-only first transplants were performed: 53 DSA-positive, 93 PRA-positive/DSA-negative and 194 unsensitized. Thirty-day survival was 96 %/99%/96% in the three groups, respectively. One-year graft survival was 89%/88%/86% (p = 0.47). DSA-positive and PRA-positive/DSA-negative patients were less likely to experience any ≥ grade 2 acute rejection (9% and 9% vs. 18% unsensitized p = 0.04). Maximum predicted forced expiratory volume (1 s) (81%/74%/76%, p = NS) and predicted forced vital capacity (81%/77%/78%, respectively, p = NS) were equivalent between groups. With the application of this perioperative treatment protocol, lung transplantation can be safely performed in DSA/PRA-positive patients, with similar outcomes to unsensitized recipients.

MATERIALS
Product Number
Brand
Product Description

USP
Mycophenolate mofetil, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Mycophenolate mofetil, ≥98% (HPLC)
Mycophenolate mofetil, European Pharmacopoeia (EP) Reference Standard
Supelco
Mycophenolate Mofetil, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
(±)-CPP, solid
Ciclosporin, European Pharmacopoeia (EP) Reference Standard
Mycophenolate mofetil for peak identification, European Pharmacopoeia (EP) Reference Standard