- Diastereo- and enantioselective asymmetric hydrogenation of α-amido-β-keto phosphonates via dynamic kinetic resolution.
Diastereo- and enantioselective asymmetric hydrogenation of α-amido-β-keto phosphonates via dynamic kinetic resolution.
Organic letters (2012-12-25)
Xiaoming Tao, Wanfang Li, Xiaoming Li, Xiaomin Xie, Zhaoguo Zhang
PMID23259640
ABSTRACT
Dynamic kinetic resolution of various α-amido-β-keto phosphonates via asymmetric hydrogenation proceeded efficiently to give the corresponding β-hydroxy-α-amido phosphonates in high diastereo- and enantioselectivities (up to 99:1 syn/anti, 99.8% ee). The addition of catalytic amounts of CeCl(3)·7H(2)O is necessary to achieve both good selectivity and catalytic efficiency under mild reaction conditions.
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