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Key Documents

1044006

USP

Aspirin

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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About This Item

Linear Formula:
2-(CH3CO2)C6H4CO2H
CAS Number:
Molecular Weight:
180.16
Beilstein:
779271
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

aspirin

manufacturer/tradename

USP

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aspirin USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard solution for impurity analysis and performance test according to the given below monographs of United States Pharmacopeia (USP):
  • Carisoprodol and Aspirin Tablets.
  • Aspirin Tablets.
  • Aspirin Boluses.
  • Butalbital, Aspirin, Caffeine, and Codeine Phosphate Capsules.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

482.0 °F

Flash Point(C)

250 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Butalbital, Aspirin, Caffeine, and Codeine Phosphate Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(2), 648-648 (2013)
Aspirin Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 392-392 (2020)
Carisoprodol and Aspirin Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 778-778 (2013)
Aspirin Boluses
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 388-388 (2017)
Gwen M C Masclee et al.
Gastroenterology, 147(4), 784-792 (2014-06-18)
Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB

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