- Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions.
Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions.
Impairments in cognitive and locomotor functions usually occur with advanced age, as do changes in brain volume. This study was conducted to assess changes in brain volume, cognitive and locomotor functions, and oxidative stress levels in middle- to late-aged rats. Forty-four male Sprague-Dawley rats were divided into four groups: 14, 18, 23, and 27months of age.