Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist.

Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist.

International journal for parasitology. Drugs and drug resistance (2016-07-12)

John D Chan, Sreemoyee Acharya, Timothy A Day, Jonathan S Marchant

RESUMEN

5-hydroxytryptamine (5-HT) is a key regulator of muscle contraction in parasitic flatworms. In Schistosoma mansoni, the myoexcitatory action of 5-HT is effected through activation of a serotonergic GPCR (Sm.5HTR

MATERIALES

Referencia del producto

Marca

Descripción del producto

14927

Supelco

Serotonin, analytical standard

SML2230

Sigma-Aldrich

Nuciferine, ≥98% (HPLC)