Presence of an H

We have recently found an H We investigated the uptake and efflux of quinidine in MDCK cells. The uptake of 100 µM quinidine into MDCK cells was decreased by acidification of extracellular pH or alkalization of intracellular pH. In addition, the uptake of quinidine was highly temperature sensitive, but was extracellular Na The present findings suggested that the renal new antiport system is involved in the bidirectional membrane transport of quinidine in MDCK cells.