- Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.
Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.
Chemical communications (Cambridge, England) (2008-05-14)
Yoshio Hayashi, Thomas Regnier, Shigenobu Nishiguchi, Magne O Sydnes, Daisuke Hashimoto, Junya Hasegawa, Takahiro Katoh, Tetsuya Kajimoto, Masataka Shiozuka, Ryoichi Matsuda, Manabu Node, Yoshiaki Kiso
PMID18473076
RESUMEN
Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.
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