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Merck
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Key Documents

SML2319

Sigma-Aldrich

TAT-Gap19 trifluoroacetate salt

≥95% (HPLC)

Sinónimos:

L-Tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-?-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine trifluoroacetate salt, YGRKKRRQRRRKQIEIKKFK trifluoroacetate salt

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About This Item

Fórmula empírica (notación de Hill):
C119H212N46O26 · xC2HF3O2
Número de CAS:
1507930-54-2
Peso molecular:
2703.25 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

TAT-Gap19 is a cell penetrant analog of a connexin 43 (Cx43) hemichannels selective blocker Gap19. TAT-Gap19 inhibits TAT-Gap19 in mice brain without affecting gap junction channels.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Verónica Abudara et al.
Frontiers in cellular neuroscience, 8, 306-306 (2014-11-07)
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct cytoplasm-to-cytoplasm and inside-out exchange
Paolo Bazzigaluppi et al.
Neurobiology of disease, 101, 1-7 (2016-12-23)
Extracellular potassium concentration, [K+]o, is a major determinant of neuronal excitability. In the healthy brain, [K+]o levels are tightly controlled. During seizures, [K+]o increases up to 15mM and is thought to cause seizures due to its depolarizing effect. Although astrocytes
Laura Walrave et al.
Frontiers in cellular neuroscience, 10, 288-288 (2017-01-10)
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via
Wei Zhang et al.
Behavioral and brain functions : BBF, 19(1), 23-23 (2023-12-19)
As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research has shown that infrasound impairs cognitive function, especially the ability for learning and memory. Previously, we demonstrated that impaired learning and memory

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