Q0875

Quinidine sulfate salt dihydrate

• Fórmula empírica (notación de Hill): C₄₀H₄₈N₄O₄ · H₂O₄S · 2H₂O
• Número de CAS: 6591-63-5
• Peso molecular: 782.94
• EC Number: 200-046-3
• MDL number: MFCD00149346
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277870
• NACRES: NA.77

Propiedades

• impurities: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp: 212-214 °C (dec.) (lit.)
• originator: Bayer
• SMILES string: [H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
• InChI key: ZHNFLHYOFXQIOW-WFTMRWCJSA-N

Descripción

General description

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

Application

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

Biochem/physiol Actions

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

Class IA antiarrhythmic; potassium channel blocker.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves