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P4553

Sigma-Aldrich

6-Phosphogluconic Dehydrogenase from yeast

lyophilized powder, ≥3.0 units/mg solid

Sinónimos:

6-Phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating), 6-Phosphogluconic Dehydrogenase from yeast

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About This Item

Número de CAS:
9073-95-4
Comisión internacional de enzimas:
1.1.1.44 (BRENDA, IUBMB)
MDL number:
MFCD00130317
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

yeast

form

lyophilized powder

specific activity

≥3.0 units/mg solid

mol wt

52 kDa

storage temp.

2-8°C

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General description

6-Phosphogluconic Dehydrogenase from yeast comprises of a NADP+ binding domain, α helical hydrophobic interaction domain and a C-terminal domain. It exists as dimer and the C-terminal region is crucial for the substrate binding and release.

Application

6-Phosphogluconic Dehydrogenase from yeast has been used in hexokinase (HK) and xylose reductase (XR) activities in cell lysate.

Biochem/physiol Actions

Enzyme activity is determined by measuring the reduction of NAD+ or NADP+. High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.

Unit Definition

One unit will oxidize 1.0 μmole of 6-phospho-D-gluconate to D-ribulose 5-phosphate and CO2 per min at pH 7.4 at 37 °C in the presence of NADP+.

Inhibitor

Referencia del producto
Descripción
Precios

I1149

Yodoacetamida, BioUltra

I6125

Yodoacetamida, ≥99% (NMR), crystalline

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Gluconate Kinase Is Required for Gluconate Assimilation and Sporulation in Cryptococcus neoformans.
Jezewski, et al.
Microbiology spectrum, 10, e0030122-e0030122 (2022)
Enhancement of xylose uptake in 2-deoxyglucose tolerant mutant of Saccharomyces cerevisiae
Kahar P, et al.
Journal of Bioscience and Bioengineering, 111(5), 557-563 (2011)
G Martínez-Drets et al.
Journal of bacteriology, 130(3), 1139-1143 (1977-06-01)
6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) (NAD+-6PGD) was detected in several slow-growing strains of rhizobia, and no activity involving NADP+ was found in the same extracts. By contrast, fast-growing strains of rhizobia had NADP+-6PGD activity; most of them also had NAD+-6PGD activity. NAD+-6PGD
Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
He W, et al.
BMC Structural Biology, 7(1), 38-38 (2007)
Ai-Hua Jin et al.
BMC structural biology, 7, 28-28 (2007-04-21)
Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4
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