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Key Documents

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M5449

Sigma-Aldrich

MKT-077

≥98% (HPLC), powder

Sinónimos:

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride, FJ-776

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About This Item

Fórmula lineal:
C21H22N3OS2Cl
Número de CAS:
147366-41-4
Peso molecular:
432.00
MDL number:
MFCD27665468
UNSPSC Code:
12352200
PubChem Substance ID:
329818014
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

orange to red

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]

InChI

1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;

Inchi Key

VSKYOTRJSLYFHX-UXJRWBAGSA-M

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Biology open, 6(4), 481-488 (2017-03-16)
Earlier studies suggested that
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PloS one, 12(2), e0170470-e0170470 (2017-02-09)
Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis
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The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate
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