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Key Documents

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M4074

Sigma-Aldrich

Mometasone furoate

≥98% (HPLC)

Sinónimos:

(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

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About This Item

Fórmula empírica (notación de Hill):
C27H30Cl2O6
Número de CAS:
83919-23-7
Peso molecular:
521.43
MDL number:
MFCD00866003
UNSPSC Code:
51111800
PubChem Substance ID:
329817988
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +50 to +60°, c = 0.5 in methanol

color

white to off-white

solubility

DMSO: ≥20 mg/mL

originator

Schering Plough

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl

InChI

1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1

InChI key

WOFMFGQZHJDGCX-ZULDAHANSA-N

Gene Information

human ... NR3C1(2908)

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Application

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

Biochem/physiol Actions

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.
Mometasone furoate is an anti-inflammatory glucocorticoid.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

An In Vitro Investigation of the Effects of the Glucocorticoid on Leishmania major Amastigotes
Renani EH, et al.
Avicenna journal of phytomedicine, 6(4), 127-132 (2019)
Inhaled Mometasone Furoate
Sharpe M and Jarvis B
Drugs, 61(9), 1325-1350 (2001)
David W Kennedy
Expert review of respiratory medicine, 6(5), 493-498 (2012-11-09)
Chronic rhinosinusitis is widely recognized as one of the most common chronic disease entities. Since its introduction in the USA in 1985, the role of functional endoscopic sinus surgery as an adjunct to medical therapy in the treatment of chronic
Environmental exposure unit: a sensitive, specific, and reproducible methodology for allergen challenge.
Anne K Ellis et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(5), 323-328 (2013-10-16)
Mohamed A Bitar et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 270(3), 931-937 (2012-09-27)
This study aimed at observing the efficacy of mometasone fuorate monohydrate nasal spray on obstructive adenoids in children and identifying the characteristics of responders using a pilot study including children aged 2-11 years, with evidence of more than 50 %
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