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Key Documents

L8643

Sigma-Aldrich

Lipopolysaccharides from Pseudomonas aeruginosa 10

purified by gel-filtration chromatography

Sinónimos:

LPS

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About This Item

MDL number:
MFCD00131520
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

Pseudomonas aeruginosa (10)

Quality Level

200

form

lyophilized powder

purified by

gel-filtration chromatography

impurities

<3% Protein (Lowry)

color

white to faint yellow

solubility

water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow

storage temp.

2-8°C

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Application

Lipopolysaccharides from Pseudomonas aeruginosa 10 has been used as an inflammatory mediator in cells.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice.
Bruscia EM
American Journal of Respiratory Cell and Molecular Biology, 40, 295-295 (2009)
Austin Boucher et al.
Journal of immunology (Baltimore, Md. : 1950), 206(3), 540-553 (2020-12-18)
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -27a, and -24-2, regulates mouse macrophage polarization.
Sandra Chang et al.
PloS one, 10(7), e0131810-e0131810 (2015-07-07)
Oxidant production from DUOX1 has been proposed to lead to neutrophil recruitment into the airways when lung homeostasis is compromised. The objective of this study was to determine whether DUOX-derived hydrogen peroxide is required for LPS-induced neutrophil recruitment, using a
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha.
Russell JP
Infection and Immunity, 64, 1565-1565 (1996)
Clara cells attenuate the inflammatory response through regulation of macrophage behavior.
Snyder JC
American Journal of Respiratory Cell and Molecular Biology, 42, 161-171 (2010)
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Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

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