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Key Documents

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D9175

Sigma-Aldrich

Dantrolene sodium salt

Sinónimos:

1-[(5-­(p-Nitro­phenyl)­fur­furyl­idene)­amino]­hydan­toin sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C14H9N4NaO5
Número de CAS:
14663-23-1
Peso molecular:
336.23
MDL number:
MFCD00079130
UNSPSC Code:
12352200
PubChem Substance ID:
24278823
NACRES:
NA.77

form

solid

Quality Level

200

originator

JHP Pharmaceuticals

SMILES string

[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChI key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

Gene Information

human ... RYR1(6261) , RYR3(6263)

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Biochem/physiol Actions

Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by JHP Pharmaceuticals. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
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Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
Z H Németh et al.
Brain research bulletin, 46(3), 257-261 (1998-07-17)
Recent studies suggested that transmitters released from the sympathetic nerve terminals can modulate various inflammatory responses by occupation of receptors on immune cells. These neurotransmitters act via alteration of intracellular concentration of second messengers. For instance, intracellular calcium as a
S K Song et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(9), 3933-3937 (1993-05-01)
Severe bloodstream-borne infection--i.e., sepsis--and the resulting multiorgan failure are now the most common cause of death in many intensive care units. One of the most fundamentally important and controversial issues concerning the pathophysiology of sepsis is the role of intracellular
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