Saltar al contenido
Merck

C3042

Sigma-Aldrich

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

Sinónimos:

CRF, CRH

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula empírica (notación de Hill):
C208H344N60O63S2
Número de CAS:
Peso molecular:
4757.45
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human
rat

Quality Level

assay

≥95% (HPLC)

form

powder

mol wt

4757.45

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, colorless

UniProt accession no.

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

¿Está buscando productos similares? Visita Guía de comparación de productos

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:
  • as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
  • as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
  • in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
  • in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Frameworks of alcohol addiction: alcohol addiction as a reward deficit and stress surfeit disorder
Frontiers in Psychiatry, 3-28 (2014)
Johannes M H M Reul et al.
Current opinion in pharmacology, 2(1), 23-33 (2002-01-12)
Corticotropin-releasing factor (CRF) and its related family members are implicated in stress-related disorders such as anxiety and depression. Recently, two new members of this neuropeptide family have been discovered in the brain: urocortin II (also known as stresscopin-related peptide) and
Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone
Thome UH, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(2), L376-L385 (2003)
Salt appetite
Vitamins & Hormones (2017)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico