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Merck

PHR1487

Supelco

Canamicina sulfate from Streptomyces kanamyceticus

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Canamicina A, Canamicina sulfate salt

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About This Item

Fórmula empírica (notación de Hill):
C18H36N4O11 · H2O4S
Número de CAS:
Peso molecular:
582.58
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 861
traceable to Ph. Eur. K0200000
traceable to USP 1355006

API family

kanamycin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Kanamycin Sulfate, generated by specific strains of Streptomyces kanamyceticus, belongs to the class of aminoglycoside antibiotics. It is known to act effectively against a broad spectrum of Gram-negative and Gram-positive bacteria.

Application

Kanamycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Modo de acción: El producto actúa uniéndose a la subunidad ribosómica 70S, inhibiendo la translocación y provocando una codificación errónea.

Modo de resistencia: las enzimas modificadoras de los aminoglucósidos (como la acetiltransferasa, la fosfotransferasa y la nucleotidiltransferasa) pueden alterar este antibiótico y evitar su interacción con los ribosomas.

Espectro antimicrobiano: El sulfato de canamicina es eficaz contra las bacterias gramnegativas y grampositivas, y contra los micoplasmas.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7808 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Certificados de análisis (COA)

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Visite la Librería de documentos

Development and validation of a novel LC/ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals
Megoulas NC and Koupparis MA
Journal of Pharmaceutical and Biomedical Analysis, 36(1), 73-79 (2004)
Quantitative determination and separation of analogues of aminoglycoside antiobiotcs by high-performance liquid chromatography
Gambardella P, et al.
Journal of Chromatography A, 348(12), 229-240 (1985)
Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection
Galanakis EG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1114-1120 (2006)
Determination of aminoglycosides in pharmaceutical formulations-II. High-performance liquid chromatography
Fabre H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 7(12), 1711-1718 (1989)

Artículos

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.

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