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Merck

N0392

Supelco

Nordoxepin hydrochloride

analytical standard, ≥98.0% (TLC), powder

Sinónimos:

11(6H)-(3-[Methylamino]propylidene)dibenz[b,e]oxepine

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About This Item

Fórmula empírica (notación de Hill):
C18H19NO · HCl
Número de CAS:
Peso molecular:
301.81
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥98.0% (TLC)

form

powder

technique(s)

HPLC: suitable

color

white to yellow

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CNCC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;

InChI key

GNPPEZGJRSOKRE-QFHYWFJHSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Doxepin metabolite.

Features and Benefits

Shelf-life of the powder is at least 10 years.

Other Notes

Mixture of cis- and trans-isomers

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
Sebastian Härtter et al.
Pharmaceutical research, 19(7), 1034-1037 (2002-08-16)
This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant doxepin to its pharmacologically active N-desmethylmetabolite by in vitro techniques. The doxepin N-demethylation was studied by means
Anna Koski et al.
The American journal of forensic medicine and pathology, 28(3), 259-261 (2007-08-28)
It has been suggested that the polymorphism of the CYP2D6 gene can contribute to occurrence of fatal adverse effects. We therefore investigated postmortem toxicology cases of fatal drug poisonings related to CYP2D6 substrates, with the manner of death denoted as
M Adamczyk et al.
Therapeutic drug monitoring, 17(4), 371-376 (1995-08-01)
A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin. A 3-microns analytical silica column (6 x 100 mm) was employed with the mobile phase
J Yan et al.
Journal of chromatography. B, Biomedical sciences and applications, 691(1), 131-138 (1997-03-28)
Doxepin is a tricyclic antidepressant marketed as an irrational mixture of cis- and trans-geometric isomers in the ratio of 15:85. A convenient high-performance liquid chromatographic (HPLC) procedure for simultaneous quantitation of geometric isomers of doxepin and N-desmethyldoxepin in plasma and

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