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Merck

18493

Millipore

MUG Supplement

suitable for microbiology

Sinónimos:

4-Methylumbelliferyl-beta-D-glucuronide Supplement

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About This Item

Fórmula empírica (notación de Hill):
C16H16O9
Número de CAS:
Peso molecular:
352.29
EC Number:
MDL number:
UNSPSC Code:
41171614
PubChem Substance ID:
NACRES:
NA.85

sterility

sterile

Quality Level

form

powder

shelf life

limited shelf life, expiry date on the label

application(s)

agriculture
environmental
food and beverages

microbiology

storage temp.

2-8°C

suitability

Escherichia coli
coliforms

SMILES string

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](C(O)=O)O[C@H]1OC2=CC(OC(C=C3C)=O)=C3C=C2

InChI

1S/C16H16O9/c1-6-4-10(17)24-9-5-7(2-3-8(6)9)23-16-13(20)11(18)12(19)14(25-16)15(21)22/h2-5,11-14,16,18-20H,1H3,(H,21,22)/t11-,12-,13+,14-,16+/m0/s1

InChI key

ARQXEQLMMNGFDU-JHZZJYKESA-N

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Application

Fluorogenic substrate for measuring of ß-glucoronidiase activity, for identifiacation of Escherichia coli.

Components

(per vial, sufficient for 500 ml medium)
4-Methylumbelliferyl ß-D-glucuronide (MUG) 50.0 mg

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Si-Cheng Liang et al.
Journal of pharmaceutical and biomedical analysis, 54(1), 236-241 (2010-09-11)
Propofol O-glucuronidation has been used as probe reaction to phenotype UGT1A9 activity in human liver, thus a sensitive and specific method for determination of propofol O-glucuronide (PG) is urgently desirable. In the current study, a new LC-ESI-MS method for determination
Adrian Unc et al.
Applied and environmental microbiology, 72(3), 2287-2289 (2006-03-07)
Laboratory batch tests indicate that addition of sterile municipal sewage biosolids to clay soil from four depths increases the numbers of Escherichia coli isolates recoverable in EC-MUG broth (EC broth with 4-methylumbelliferyl-beta-glucuronide). This effect was most marked for the deeper
Upendra A Argikar et al.
Drug metabolism and pharmacokinetics, 26(1), 102-106 (2010-11-19)
Standard incubation procedures for carrying out microsomal assays involve the use of less than 1% w/v organic solvents to minimize the potential inhibitory effects of organic solvents on metabolic activity. This presents a practical limitation for poorly soluble xenobiotics, which
M Grube et al.
Naunyn-Schmiedeberg's archives of pharmacology, 368(6), 463-469 (2003-11-18)
A promising development in tumor therapy is the application of non-toxic prodrugs from which the active cytostatic is released by endogenous enzymes such as beta-glucuronidase (beta-gluc). Regulation of beta-gluc expression is one crucial factor modulating bioactivation of prodrugs. Recent experiments
Helmut Kallwass et al.
Molecular genetics and metabolism, 90(4), 449-452 (2007-02-03)
The enzymatic defect in Pompe disease is insufficient lysosomal acid alpha-glucosidase (GAA) activity which leads to lysosomal glycogen accumulation. We recently introduced a simple and reliable method to measure GAA activity in dried blood spots using Acarbose, a highly selective

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